2005年上海华东师范大学基因组学及演唱考研真题.doc-资料库

2005 年上海华东师范大学基因组学及演唱考研真题基因组学一、名词解释（10 分/题，共 50 分） 1、结构基因组学与功能基因组学 _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 2、基因组遗传图与物理图谱 _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 3、SNPs and ESTs _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 4、Knock-down and Knock-out _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 5、siRNA and shRNA _______________________________________________________________________________

_______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 二、问答题（20 分/题，共 100 分） 1、简述人类基因组计划研究的意义和现状。 _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 2、如何鉴定人类孟德尔遗传疾病的致病基因? _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 3、试述采用 RNA 干扰技术研究基因功能的基本策略和方法。 _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 4、简述采用基因组学方法进行高通量药物筛选的一般原理和基本策略。 _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 5、如何研究某一特定组织在病理状态下的蛋白组学变化? 请简述其研究策略和基本技术。 _______________________________________________________________________________

_______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________ 演唱自选中外艺术歌曲、歌剧咏叹调六首，演唱其中三首（自定两首，现场指定一首）。 _______________________________________________________________________________ _______________________________________________________________________________ _______________________________________________________________________________ _____________________________________________

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2005年上海华东师范大学基因组学及演唱考研真题.doc

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