To: Cancer Research George C. Prendergast, PhD, Editor-in-Chief Re: xxxx et al. Manuscript on _____________. Dear Editor(s), Available for your review is our manuscript entitled “___________” submitted for publication in Cancer Research. The current manuscript describes for the first time______. Our results further indicate that _______. All authors of this research paper have directly participated in the planning, execution, or analysis of the study. All authors of this paper have read and approved the final version submitted. The contents of this manuscript have not been copyrighted or published previously. The contents of this manuscript are not under consideration for publication elsewhere. The contents of this manuscript will not be copyrighted, submitted, or published elsewhere while acceptance by the manuscript is under consideration. There are no directly related manuscripts or abstracts, published or unpublished, by any author(s) of this paper. We thank you for your time and consideration of this manuscript. Sincerely, XXXXX,MD