Microsoft.Office.Interop.Excel.Application excel = new Micros oft.Office.Interop.Excel.Application(); excel.Workbooks.Open("d:/test5.xlsx"); excel.Cells[1, 1] = "150.236"; excel.Cells[1, 2] = "120.369"; excel.Cells[1, 4] = "100.3251"; excel.Cells[1, 5] = "100.3251"; excel.Visible = false; var missing = System.Reflection.Missing.Value; excel.Workbooks[1].Save(); excel.Workbooks[1].Close(null, null, null); excel.Quit(); 注意 excel 中 1 是首位 而不是 0；